Цвет сайта
Изображения
Для слабовидящих

ИНСТИТУТ  БИОМЕДИЦИНСКИХ  ИССЛЕДОВАНИЙ

ФИЛИАЛ ФЕДЕРАЛЬНОГО ГОСУДАРСТВЕННОГО БЮДЖЕТНОГО УЧРЕЖДЕНИЯ НАУКИ
ФЕДЕРАЛЬНОГО НАУЧНОГО ЦЕНТРА  «ВЛАДИКАВКАЗСКИЙ НАУЧНЫЙ ЦЕНТР
РОССИЙСКОЙ АКАДЕМИИ НАУК» 

Text/HTML

Text/HTML

Синдром нетиреоидных заболеваний: современное состояние проблемы и перспективы ее изучения

 

Яглова Н.В., Березов Т.Т.


Обзор посвящен проблеме функциональных расстройств щитовидной железы при различных соматических заболеваниях, известных под названием синдрома нетиреоидных заболеваний. В статье представлен анализ результатов клинических и экспериментальных исследований синдрома нетиреоидных заболеваний, его патогенеза, а также роли отдельных факторов, обеспечивающих продукцию, транспорт и метаболизм гормонов щитовидной железы.


Ключевые слова: щитовидная железа, синдром нетиреоидных заболеваний, патогенез

Литература

1.     Кетлинский С.А. Цитокины. СПб.: ООО «Издательство Фолиант», 2008. 552с.

2.     Яглова Н.В. Взаимосвязь функциональной активности  щитовидной железы и уровня провоспалительных и иммунорегуляторных цитокинов при остром экспериментальном эндотоксикозе // Бюл. эксперим. биол. и мед. 2009. Т. 49. №6. С.635-638.

3.     Яглова Н.В. Роль поляризации иммунного ответа в развитии синдрома нетиреоидных заболеваний // Вопр. биол., мед. и фарм. химии. 2009. №4. С.17-20.

4.     Яглова Н.В. Регуляция секреторных процессов в фолликулярных тироцитах щитовидной железы при экспериментальном синдроме нетиреоидных заболеваний, обусловленном острым эндотоксикозом // Актуальные вопросы морфогенеза в норме и патологии: сб. науч. тр. 2010. С.212-216.

5.     Яглова Н.В. Регуляторная роль липополисахарида в функциональной деятельности щитовидной железы и гипофиза // Биомедицинская химия. 2010. Т.56. №2. С.176-187.

6.     A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2 / A. Coppola et al. // Cell Metab. 2007. V.5, №1. P.21-33.

7.     Adaptation to hypocaloric feeding: physiologic significance of the fall in serum T3 as measured by the pulse wave arrival time / R. Osburne et al. // Metabolism. 1983. V.32. №1. P.9-13.

8.     Altered expression of nuclear hormone receptors and coactivators in mouse heart during the acute-phase response / K. Feingold et al. // American J. of Physiology and Metabolism. 2004. V.286. №2. P.E201-E207.

9.     Bacterial Lipopolysaccharide Stimulates the Thyrotropin-Dependent Thyroglobulin Gene Expression at the Transcriptional Level by Involving the Transcription Factors Thyroid Transcription Factor-1 and Paired Box Domain Transcription Factor 8 / M. Vélez et al. // Endocrinology. 2006. V. 147. №7. P. 3260-3275.

10.  Beckett G. Thyroid function and thyroid function tests in non-thyroidal illness // CPD Bulletin: Clinical Biochemistry. 2006. V.7. P.107-116.

11.  Biochemistry, cellular and molecular biology, and physiological roles of the iodothyronine selenodeiodinases / A. Bianco et al. // Endocr. Rev. 2002. V.23. №1. P.38-89.

12.  Boelen A. et al. Association between serum interleukin-6 and serum 3,5,3’-triiodothyronine in nonthyroidal illness // J. Clin. Endocrinol. Metab. 1993. V.80. №6. P.1695-1699.

13.  Boelen A. Immunoneutralization of interleukin-1, tumor necrosis factor, interleukin-6 or interferon does not prevent the LPS-induced sick euthyroid syndrome in mice // J. Endocrinol. 1997. Vol.153. №1. Р.115-122.

14.  Boelen A. et al. Relationsheep between serum 3,5,3’-triiodothyronine and serum interleukin-8, interleukin-10 or interferon gamma in patients with nonthyroidal illness // J. Endocrinol. Invest. 1996. V.19. №7. P.480-483.

15.  Brent G. et al. Thyroxine therapy in patients with severe non-thyroidal illnesses and lower serum thyroxine concentration // J. Clin. Endorinol. Metab. 1986. V.63. №1. P.1-8.

16.  Changes in thyroid hormone parameters after acute myocardial infarction / B. Eber et al. // Cardiology. 1995. V.86. №2. P.152-156.

17.  Characterization of T4-binding globulin cleaved by human leukocyte elastase / O. Janssen et al. // J. Clin. Endorinol. Metab. 2002. V.87. №3. P.1217-1222.

18.  Chiamolera M. et al. Thyrotropine-releasing hormone and the thyroid hormone feedback mechanism // Endocrinology. 2009. V.150.№3. P.1091-1096.

19.  Chopra I. Clinical review 86: euthyroid sick syndrome: is it a misnomer? // J. Clin. Endocrinol. Metab. 1997. V.82.№2. P.329-334.

20.  Circulating thyroid hormone changes in acute trauma: prognostic implications for clinical outcome / R. Phillips et al. // J. Trauma. 1984. V.24. №2. P.116-119.

21.   Contribution of interleukin-12 to the pathogenesis of nonthyroidal illness / A. Boelen et al. // Hormone and Metabolic Research. 2004. V.36.№2. P.101-106.

22.  Dayan C. et al. Novel insights into thyroid hormones from the study of common genetic variation// Nat. Rev. Endocrinol. 2009. V.5. №4. P.211-218.

23.  De Groot L. Non-thyroidal illness syndrome is a manifestation of hypothalamic-pituitary disfunction, and in view of current evidence, should be treated with appropriate replasement therapies. // Crit. Care Clin. 2006. V.22.№1. P.57-86.

24.  Differential interactions between Th1/Th2, Th1/Th3, and Th2/Th3 cytokines in the regulation of thyreoperoxidase and dual oxidase expression, and of thyroglobulin secretion in thyrocytes in vitro / S. Poncin et al. // Endocrinology. 2008. V.149.№4. P.1534-1542.

25.  Distinct tissue-specific roles for thyroid hormone receptors beta and alpha1 in regulation of type1 deiodinase expression / L. Amma et al. // Mol. Endocrinol. 2001. V.15. №3. P.467-475.

26.  Do thyroid function tests independently predict survival in the critically ill? / S. Maldonado et al. // Thyroid. 1992. V.2. №2. P.119-123.

27.  Effect of starvation, nutriment replacement, and hypothyroidism on in vitro hepatic T4 to T3 conversion in the rat / A. Harris et al. // Metabolism. 1978. V.27. №11. P.1680-1690.

28.  Endocrine and metabolic responses in children with meningococcal sepsis: striking differences between survivors and nonsurvivors / K. Joosten et al. // J. Clin. Endocrinol. Metab. 2000. V.85. №10. P.3746-3753.

29.  Endotoxin stimulates leptin in the human and nonhuman primate/ R. Landman et al. // J. Clin. Endocrinol. Metab. 2003. V.88. №3. P.1285-1291.

30.  Euthyroid sick syndrome in meningococcal sepsis: the impact of peripheral thyroid hormone metabolism and binding proteins / M. Den Brinker M. et al. // J. Clin. Endorinol. Metab. 2005. V.90. №10. P.5613-5620.

31.  Evidence for an inhibitor of extrathyroidal conversion of thyroxine to 3,5,3’-triiodothyronine in sera of patients with non-thyroidal illness / I. Chopra et al. // J. Clin. Endorinol. Metab. 1985. V.60. №4. P.666-672.

32.  Expression and regulation of type II iodothyronine deiodinase in cultured human skeletal muscle cell / Y. Hosoi et al. // J. Clin. Endocrinol. Metab. 1999. V.84. №9. P.3293-3300.

33.  Expression of thyroid hormone transporters during critical illness / L. Mebis et al. // Eur. J. Endocrinol. 2009. V.161. №2. P.243-250.

34.  Fatty acid-induced increase of serum dialyzable free thyroxine after physical exercise: implication for nonthyroidal illness / K. Liewendahl et al. // J. Clin. Endorinol. Metab. 1992. V.74. №6. P.1361-1365.

35.  Functional Toll-Like Receptor 4 Conferring Lipopolysaccharide Responsiveness Is Expressed in Thyroid Cells / J. Nicola et al. // Endocrinology. 2009. V.150. №1. P. 500-508.

36.  Hypermetabolic low triiodothyronine syndrome of burn injury / R. Becker et al. // Crit. Care Med. 1982. V.10. №12. P.870-875.

37.  Identification of molecular mechanisms related to nonthyroidal illness syndrome in skeletal muscle and adipose tissue from patients with septic shock / A. Rodriguez-Perez et al. // Clin. Endocrinol. 2008. V.68. №5. P.821-827.

38.  Inability to detect an inhibitor of thyroxine-serum protein binding in sera from patients with non-thyroidal illness / C. Mendel et al. // Metabolism. 1991. V.40. №5. P.491-502.

39.  Innate immunity modulates adipokines in humans. / P. Anderson et al. // J. Clin. Endocrinol. Metab. 2007. V.92. №6. P.2272-2279.

40.  Insulin resistance and substrate utilization in human endotoxinemia A. / Agwunobi et al. // J. Clin. Endocrinol. Metab. 2000. V.85, №10. P.3770-3778.

41.  Interleukin-1 receptor blockade does not affect endotoxin-induced changes in plasma thyroid hormone and thyrotropine concentration in man / T. Van der Poll et al. // J. Clin. Endocrinol. Metab. 1995. V.80. №4. P.1341-1346.

42.  Interleukin-18, a proinflammatory cytokine, contributes to the pathogenesis of nonthyroidal illness mainly via the central part of the hypothalamus-pituitary-thyroid axis / A. Boelen et al. // Eur. J. Endocrinol. 2004. V.15. №4. P.497-502.

43.  Iodothyronine deiodinase activities in fetal rat tissues at several levels of iodine deficiency: a role for the skin in 3,5,3’-triiodothyronine economy / J. Schroder-van der Elst et al. // Endocrinilogy. 1998. V.139. №5. P.2229-2234.

44.  Kaptein E. Clinical relevance of thyroid hormone alterations in nonthyroidal illness // Thyroid International. 1997. V.4. P.22-25.

45.  Kaptein E. Thyroid hormone metabolism and thyroid diseases in chronic renal failure // Endocr. Rev. 1996. V.17.№1. P.45-63.

46.  Lacking thyroid hormone beta does not influence alterations in peripheral thyroid hormone metabolism during acute illness / J. Kwakkel et al. // J. Endocrinol. 2008. V.197. №1. P.151-158.

47.  Leonard J. Intracellular pathways of iodothyronine metabolism / J. Leonard, Kohrle J. // In: L. Braverman , R. Utiger R. (eds) - The Thyroid, 8th ed. Phipadelphia: Lippincot-Raven, 2000. P.136-173.

48.  Life without T4 to T3 conversion: studies in mice devoid of the 5’-deiodinases / V. Galton et al. // Endocrinology. 2009. V.150. №6. P.2957-2963.

49.  Miyake K. Endotoxin recognition molecules, Toll-like receptor 4-MD-2 // Semin. Immunol. -  2004. V.16. №1. P.11–16.

50.  On the albumin dependence of the measurement of free thyroxine. II. Patients with non-thyroidal illness / G. Csako et al. // Clin. Chem. 1987. V.33. №1. P.87-92.

51.  Rasmussen A. Cytokine actions oh the thyroid gland // Dan. Med. Bull. 2000. V.47. №2. P.94-114.

52.  Selective consumption of thyroxine-binding globulin during cardiac bypass surgery. / B. Afandi et al. // Metabolism. 2000. V.49. №2. P.270-274.

53.  Serum 3,3’,5’-triiodothyronone (rT3) and 3,5,3’-triiodothronine/rT3 are prognostic markers in critically ill patients and are associated  with postmortem tissue deiodinase activities. / R. Peeters et al. // J. Clin. Endorinol. Metab. 2005. V.90. №8. P.4559-4565.

54.  Sick euthyroid syndrome is associated with decreased TR expression and DNA binding in mouse liver / A. Beigneux et al. // Amer. J. of Physiology and Metabolism. 2003. V.284. №1. P.E228-E236.

55.  Simultaneous changes in central and peripheral components of the hypothalamus-pituitary-thyroid axis in lipopolysaccharide induced acute illness in mice / A. Boelen et al. // J. Endocrinol. 2004. V.182.№2. P.315-323.

56.  St.Germain D. Defining the roles of iodothyronine deiodinases: current concepts and challenges. // Endocrinilogy. 2009. V.150.№6. P.1097-1107.

57.  St.Germain D. et al. The deiodinases family of selenoproteins // Thyroid. 1997. V.7. №4. P.655-668.

58.  Suppression of iodide uptake and thyroid hormone synthesis with stimulation of the type I interferon system by double-stranded ribonucleic acid in cultured human thyroid follicles / K. Yamazaki et al. // Endocrinology. 2007. V.148. №7. P.3226-3235.

59.  Takaya K., Alterations of plasma ghrelin levels in rats with lipopolysaccharide induced wasting syndrome and effects of ghrelin treatment on the syndrome // Endocrinology. 2003. V.144. №12. P.5365-5371.

60.  The “euthyroid sick syndrome”: incidence, risk factor and prognostic value soon after allogenic bone marrow transplantation / P.Vexiau et al. // Br. J. Hematol. 1993. V.85. №.4. P.778-782.

61.  The role of cytokines in the lipopolisaccharide-induced sick euthyroid syndrome in mice. / A. Boelen et al. // J. Endocrinol. 1995. V.146. №3. P.475-483.

62.  The type I iodothyronine 5’-deiodinase mRNA is localized to S3 segment of the rat kidney proximal tubule / W. Lee et al. // Endocrinilogy. 1993. V.132. №5. P.2136-2140.

63.  Therapeutic effects of ghrelin on endotoxic shock in rats. / L. Chang et al. // Eur. J. Pharmacol. 2003. V.473. №2-3. P.171-176.

64.  Thyroid hormone receptor expression in the “euthyroid sick” syndrome / G. Williams et al. // Lancet. 1989. №2(8678-8679). P.1477-1481.

65.  Thyroid hormone receptor α modulates lipopolysaccharide-induced changes in peripheral thyroid hormone metabolism / J. Kwakkel et al. // Endocrinology. 2010. V.151. №4. P.1959-1969.

66.  Thyroid hormone transport in and out of cells / W. Visser et al. // Trends in Endocrinology and metabolism. 2008. V.19. №2. P.50-56.

67.  Visser T. Thyroid hormone transport by monocarboxylate transporters // Best Pract. Res. Clin. Endocrinol. Metab. 2007. V.21. .2. P.223-236.

68.  Warner M. et al. Mechanism behind the non-thyroidal illness syndrome: an update // J. Endocrinol. 2010. V.205. №1. P.1-13.

69.  Yu J., Koenig R. Induction of type I iodothyronine deiodinase to prevent the nonthyroidal illness syndrome in mice// Endocrinology. 2006. V.147. №7. P.3580-3585.

70.  Yu J., Koenig R. Regulation of hepatocyte thyroxine 5’-deiodinase by T3 and nuclear receptor coactivators as a model of euthyroid sick syndrome // J. Biol. Chem. 2000. V.275. №49. P.38296-38301.